Protein Homeostasis in Health and Disease- Cold Spring Harbor
Protein Homeostasis in Health and Disease
April 24 – 28, 2024
Abstract Deadline: February 20, 2024
Organizers:
Judith Frydman, Stanford University
Malene Hansen, Buck Institute for Research on Aging
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Richard Morimoto, Northwestern University
Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.
You are invited to participate in the 16th meeting on Protein Homeostasis in Health & Disease. Groundbreaking work – on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease – has first been presented at this meeting over the past three decades plus. The 2024 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.
The meeting will begin after dinner at 7:30 p.m. on Wednesday, April 24, and conclude with lunch on Sunday, April 28, 2024.
Topics & Session Chairs:
Cell Stress Response Signaling in Biology, Aging and Disease
Chairs:
David Ron, University of Cambridge
Lea Sistonen, University of Turku
Chaperone Mechanisms
Chairs:
Johannes Buchner, Technical University of Munich
Helen Saibil, Birkbeck College
Co-translational Folding and Ribosome Quality Control Mechanisms
Chairs:
Toshi Inada, University of Tokyo
Elke Deuerling, University of Konstanz
Stress Granules, Phase Transitions and Intrinsically Disordered Proteins
Chairs:
Simon Alberti, Technical University Dresden
Manajit Hayer-Hartl, Max Planck Institute of Biochemistry Martinsried
Degradation Mechanisms – Autophagy Lysosomal Pathway and the Ubiquitin Proteasome System
Chair:
Ana Maria Cuervo, Albert Einstein College of Medicine
Dan Finley, Harvard Medical School
Misfolding and Aggregation in Aging and Neurodegenerative Diseases
Chairs:
Anne Bertolotti, MRC Laboratory of Molecular Biology
Byron Caughey, Rocky Mountain Laboratory, NIAID
Organellar Proteostasis and Spatial Quality Control in Aging and Disease
Chairs:
Johannes Hermann, University of Kaiserslautern
Thomas Langer, Max Planck Institute for Biology of Aging Cologne
Therapeutic Strategies for Protein Conformational Diseases of Aging
Chairs:
Jeff Kelly, Scripps Research
Peter Walter, Altos Laboratories
Panel Discussion: Preparing for Diverse Careers in Science
The format of the meeting will include eight oral sessions and two poster sessions. Each oral session will include invited speakers and speakers selected from submitted abstracts. For this reason, abstracts from accomplished junior and senior investigators are warmly invited. The abstracts should focus on new and unpublished data. The organizers will select abstracts for oral or poster presentations. The status (talk/poster) of abstracts will be posted on our web site (below) as soon as decisions have been made. We have applied for funds from government and industry to partially support graduate students and postdocs. Please apply in writing via email to Kelley McGrath and state your financial needs; preference will be given to those who submit abstracts.
All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submissions, or any other matters may be directed to Kelley McGrath.
Social Media: The designated hashtag for this meeting is #cshlprotein. Note that you must obtain permission from an individual presenter before live-tweeting or discussing his/her talk, poster, or research results on social media. Click the Policies tab above to see our full Confidentiality & Reporting Policy.
This conference is supported in part by funds provided by the National Institute on Aging of the National Institutes of Health.
Pricing:
Academic/Media Private Room/Private Bath Package: $1,775
Academic/Media Private Room/Shared Bath Package: $1,665
Academic Shared Room Package: $1,515
Academic/Media No-Housing Package: $1,130
Student Package*: $1,410
Student No-Housing Package: $1,025
Corporate Private Room/Private Bath Package: $2,270
Corporate No-Housing Package: $1,625
*Student Housing is default double occupancy. Please enquire about availability and fees to upgrade to private room.
Room packages close 2 weeks before the meeting start date
Rules for Virtual Participation: Virtual participation will include access to the oral sessions via Zoom, access to the digital poster sessions and access to the Slack discussion channel, and the Leading Strand video archive.
Presenters: Individuals submitting abstracts and facing financial barriers should firstly request financial aid (see above). Permission to present your talk or poster virtually will be given only in exceptional circumstances and on a case-by-case basis. If you think you are eligible for an exemption from the requirement to present in person, please provide a justification in writing via email to Kelley McGrath.
Non-presenting participants: We plan to broaden access to the conference by allowing certain categories of non-presenting participants to attend virtually at reduced fees. Categories include:
1. Individuals from low & middle income countries;
2. Individuals from non-LMIC countries in Asia, Australasia, Africa or South America;
3. Individuals from US & Canadian minority serving institutions;
4. Individuals with a demonstrable financial barrier;
5. Individuals with family obligations or other special circumstances.
For categories 4 & 5 above, please provide a justification via email to Kelley McGrath.
Molecular chaperones in cancer and protein quality control- Madrid, Spain
Molecular Chaperones in Cancer and Protein Quality Control
Dates: 10/06/2024 – 12/06/2024
Venue: CNIO Auditorium
Registration https://apps.cnio.es/eventos/form01.asp?ev=1&cev=333&idiomaForm=en
Application deadline May 27 2024
Abstract submission deadline May 16 2024
fee 200 Euro Students, CNIO staff and CNIO Alumni; 400 Euro Post-docs and Academia; 600 Euro Industry
Organizers Gabriela Chiosis, Memorial Sloan Kettering Institute, NY, US – Nabil Djouder, CNIO, Madrid, Spain – Judith Frydman, Stanford University, US – Oscar Llorca, CNIO, Madrid, Spain – Paul Workman,The Institute of Cancer Research, London, UK
Speakers:
Dr. Udai Banerji – The Institute of Cancer Research; The Royal Marsden NHS Foundation Trust
Dr. Jeffrey L. Brodsky – University of Pittsburgh, Kenneth P. Dietrich School of Arts and Sciences
Dr. Johannes Buchner – Technical University of Munich
Dr. Eugenia Clerico – University of Massachusetts Amherst
Dr. Benoit Coulombe – Montreal Clinical Research Institute (IRCM), University of Montreal
Dr. Chengkai Dai – Center for Cancer Research, National Cancer Institute
Dr. Elke Deuerling – Konstanz University
Dr. Manajit Hayer-Hartl – Max-Planck-Institute of Biochemistry
Dr. Walid Houry – Biochemistry, University of Toronto
Dr. Ursula Jakob – University of Michigan
Dr. Matthias Mayer – Center for Molecular Biology Heidelberg – ZMBH
Dr. Leonard Neckers – Center for Cancer Research, National Cancer Institute
Dr. Rahul Samant – Babraham Institute
Dr. Ritwick Sawarkar – University of Cambridge
Dr. Lea Sistonen – Turku Centre for Biotechnology
Dr. Peter Walter – Altos Lab, University of California
Protein Folding in the Cell- Southbridge, MA
In 1990, this conference was the first to bring together cell biologists, biophysical scientists, chemists, and physician-scientists from the global community to study this important discipline. Since then, organizers have continued to create programs every year that probe the basic scientific underpinning of the maintenance of cellular and extracellular proteostasis and to this day, remains the flagship conference in the field.
This year’s conference will focus on the latest developments regarding how native conformations of cellular and secreted proteins are achieved and maintained, and what occurs when aberrant protein conformations arise, such as those seen in Alzheimer’s Disease and dementias of aging. The meeting’s focus is on the basic science defining protein homeostasis, enabled by 2500 genes encoding the proteostasis network, comprising molecular chaperones and co-chaperones that make folding versus degradation decisions, the latter mediated by the proteasome and lysosome. A decline in proteostasis capacity is especially prominent during aging-associated disease settings, including Alzheimer’s Disease and related dementias, and understanding these mechanisms is highly relevant for developing new therapeutic strategies.
Special emphasis will be placed on both formal presentations and informal networking for fellow scientists to collaborate via discussions and group brainstorming sessions that will bring fresh and new ideas for the next generation of research. This meeting will also empower early-career scientists, especially those from historically excluded groups, to participate and present their research during the sessions.
Goals and Takeaways
· A general understanding of cellular proteostasis network function and regulation
· A deeper insight into how cellular proteostasis network dysfunction leads to dementia.
· New knowledge of how the proteostasis network and its regulation changes with aging.
· Strategies for addressing and ameliorating aging-associated neurodegenerative diseases.
Program Topics
· Folding Energy Landscapes with and without Chaperones
· Cellular Machineries of Protein Folding and Degradation
· Quality Control in Organelles
· Condensate Formation under Physiological and Pathological Conditions
· Protein Folding and Misfolding in Aging and Age-Associated Diseases
· Regulation of Protein Homeostasis in Aging
· Strategies for Ameliorating Aging-Associated Neurodegenerative Diseases
Workshops
Meet the Expert sessions will be held, covering topics such as career trajectory, grant writing, diversity, and inclusion.
Career Development Workshops will be held focusing on academic and industry career paths.
Keynote Speaker
David Agard, PhD, Professor, University of California, San Francisco, CA
Elke Deuerling, PhD, Professor, University of Konstanz, Germany
Ignite Career Forum (Pre-conference Workshop)
The Pre-conference Workshop, “Ignite Career Forum”, will be held on Sunday from 11 AM to 5 PM. Separate registration is required ($45 per person). Attendees may add the Ignite Career Forum during the registration process. Please check the Online Agenda for detailed information.
We invite graduate students, post-docs and research scientists to present their work in a friendly and collaborative environment in the form of a short talk (15 min). The best three talks will be awarded a spot in the main-meeting. We especially encourage scientists from historically excluded groups to apply. Cost of travel and meeting will be partially reimbursed for our invited speakers. Those interested in giving a talk must submit an abstract describing their research including a statement of diversity. The chair of the Ignite Career Forum will select talks from abstracts submitted by April 15th.
Location and Venue
Wellsworth Hotel (formerly the Southbridge Hotel & Conference Center)
14 Mechanic Street
Southbridge, MA 01550
USA
Important Dates
Abstract Submission Deadline for the Ignite Career Forum (Pre-meeting Workshop): April 15, 2024
Abstract Submission Deadline: May 12, 2024
Early Registration Closes: May 26, 2024
Last Day to Cancel Registration: June 17, 2024
Housing Deadline: June 23, 2024
Regular Registration Closes: July 2, 2024
Conference Organizers
Ursula Jakob, PhD
Patricia S. Yaeger Collegiate Professor
University of Michigan, Ann Arbor, MI
Jeffery Kelly, PhD
Lita Annenberg Hazen Professor of Chemistry
Scripps Research, La Jolla, CA
