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Publications

Author/sPublication TitleYear
Elia, L.P., Mason, A.R., Amela, A., Finkbeiner, S. Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway 2019
Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, et al. Soberanes et al., Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis, Cell Metabolism (2018), https://doi.org/10.1016/j.cmet.2018.09.019.(2018).2018
Stoeger T, Gerlach M, Morimoto RI, Nunes Amaral LA. Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol. 2018 Sep 18;16(9):e2006643. doi: 10.1371/journal.pbio.2006643. eCollection 2018 Sep. PubMed PMID: 30226837; PubMed Central PMCID: PMC6143198.2018
Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI.Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038. PubMed PMID: 29117555; PubMed Central PMCID: PMC5726777.2017
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau
B, Nillegoda NB.
In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10. PubMed PMID: 29024389; PubMed Central PMCID: PMC5676055.2017
Li J, Labbadia J, Morimoto RI.Rethinking HSF1 in Stress, Development, and Organismal Health. Trends Cell Biol. 2017 Dec;27(12):895-905. doi: 10.1016/j.tcb.2017.08.002. Epub 2017 Sep 7. Review. PubMed PMID: 28890254; PubMed Central PMCID: PMC5696061.2017
Alves LGA, Winter PB, Ferreira LN, Brielmann RM, Morimoto RI, Amaral LAN.Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress. Phys Rev E. 2017 Aug;96(2-1):022417. doi: 10.1103/PhysRevE.96.022417. Epub 2017 Aug 29. PubMed PMID: 28950588; PubMed Central PMCID: PMC6011659.2017
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, et al.Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. PubMed PMID: 28694385; PubMed Central PMCID: PMC5551573.2017
Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M.Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26. PubMed PMID: 28652376; PubMed Central PMCID: PMC5514703.2017
Sala AJ, Bott LC, Morimoto RI.Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol. 2017 May 1;216(5):1231-1241. doi: 10.1083/jcb.201612111. Epub 2017 Apr 11. Review. PubMed PMID: 28400444; PubMed Central PMCID: PMC5412572.2017
Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, et al. Spinal motor neuron protein supersaturation patterns are associated
with inclusion body formation in ALS. Proc Natl Acad Sci U S A. 2017 May
16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10. PubMed
PMID: 28396410; PubMed Central PMCID: PMC5441770.
2017
Li J, Chauve L, Phelps G, Brielmann RM, Morimoto RI.E2F coregulates an
essential HSF developmental program that is distinct from the heat-shock
response. Genes Dev. 2016 Sep 15;30(18):2062-2075. Epub 2016 Sep 29. PubMed PMID:
27688402; PubMed Central PMCID: PMC5066613.
2016
Winter PB, Brielmann RM, Timkovich NP, Navarro HT, Teixeira-Castro A, et al. A network approach to discerning the identities of C. elegans in a free moving population. Sci Rep. 2016 Oct 11;6:34859. doi: 10.1038/srep34859. PubMed PMID: 27725712; PubMed Central PMCID: PMC5057085.2016
Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M.A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11. PubMed PMID: 27071083; PubMed Central PMCID: PMC4855616.2016
Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L,
Silva-Fernandes A, et al.
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain. 2015 Nov;138(Pt 11):3221-37. doi: 10.1093/brain/awv262. Epub 2015 Sep 15. PubMed PMID: 26373603; PubMed Central PMCID: PMC4731417.2015
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, et al. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5. PubMed PMID: 26245380; PubMed Central PMCID: PMC4830470.2015
Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, et al. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29. PubMed PMID: 26228940; PubMed Central PMCID: PMC4570520.2015
Brandvold KR, Morimoto RI.The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol. 2015 Sep 11;427(18):2931-47. doi: 10.1016/j.jmb.2015.05.010. Epub 2015 May 21. Review. PubMed PMID: 26003923; PubMed Central PMCID: PMC4569545.2015
Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, et al. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032. Erratum in: Cell. 2017 Feb 23;168(5):944. PubMed PMID: 25957690; PubMed Central PMCID: PMC4643853.2015
Labbadia J, Morimoto RI. The biology of proteostasis in aging and disease. Annu Rev Biochem. 2015;84:435-64. doi: 10.1146/annurev-biochem-060614-033955. Epub 2015 Mar 12. Review. PubMed PMID: 25784053; PubMed Central PMCID: PMC4539002.2015
van Oosten-Hawle P, Morimoto RI. Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes Dev. 2014 Jul 15;28(14):1533-43. doi: 10.1101/gad.241125.114. Review. PubMed PMID: 25030693; PubMed Central PMCID: PMC4102760.2014
Labbadia J, Morimoto RI. Proteostasis and longevity: when does aging really begin? F1000Prime Rep. 2014 Feb 3;6:7. doi: 10.12703/P6-7. eCollection 2014. Review. PubMed PMID: 24592319; PubMed Central PMCID: PMC3914504.2014
Morimoto RI, Cuervo AM.Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):167-70. doi: 10.1093/gerona/gln071. Epub 2009 Feb 19. Review. PubMed PMID: 19228787; PubMed Central PMCID: PMC2655025.2009
Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science. 2008 Feb 15;319(5865):916-9. doi: 10.1126/science.1141448. Review. PubMed PMID: 18276881.2008