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Publications

Author/sPublication TitleYear
Elia, L.P., Mason, A.R., Amela, A., Finkbeiner, S. Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway 2019
Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, et al. Soberanes et al., Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis, Cell Metabolism (2018), https://doi.org/10.1016/j.cmet.2018.09.019.(2018).2018
Stoeger T, Gerlach M, Morimoto RI, Nunes Amaral LA. Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol. 2018 Sep 18;16(9):e2006643. doi: 10.1371/journal.pbio.2006643. eCollection 2018 Sep. PubMed PMID: 30226837; PubMed Central PMCID: PMC6143198.2018
Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI.Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038. PubMed PMID: 29117555; PubMed Central PMCID: PMC5726777.2017
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau
B, Nillegoda NB.
In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10. PubMed PMID: 29024389; PubMed Central PMCID: PMC5676055.2017
Li J, Labbadia J, Morimoto RI.Rethinking HSF1 in Stress, Development, and Organismal Health. Trends Cell Biol. 2017 Dec;27(12):895-905. doi: 10.1016/j.tcb.2017.08.002. Epub 2017 Sep 7. Review. PubMed PMID: 28890254; PubMed Central PMCID: PMC5696061.2017
Alves LGA, Winter PB, Ferreira LN, Brielmann RM, Morimoto RI, Amaral LAN.Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress. Phys Rev E. 2017 Aug;96(2-1):022417. doi: 10.1103/PhysRevE.96.022417. Epub 2017 Aug 29. PubMed PMID: 28950588; PubMed Central PMCID: PMC6011659.2017
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, et al.Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. PubMed PMID: 28694385; PubMed Central PMCID: PMC5551573.2017
Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M.Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26. PubMed PMID: 28652376; PubMed Central PMCID: PMC5514703.2017
Sala AJ, Bott LC, Morimoto RI.Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol. 2017 May 1;216(5):1231-1241. doi: 10.1083/jcb.201612111. Epub 2017 Apr 11. Review. PubMed PMID: 28400444; PubMed Central PMCID: PMC5412572.2017
Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, et al. Spinal motor neuron protein supersaturation patterns are associated
with inclusion body formation in ALS. Proc Natl Acad Sci U S A. 2017 May
16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10. PubMed
PMID: 28396410; PubMed Central PMCID: PMC5441770.
2017
Li J, Chauve L, Phelps G, Brielmann RM, Morimoto RI.E2F coregulates an
essential HSF developmental program that is distinct from the heat-shock
response. Genes Dev. 2016 Sep 15;30(18):2062-2075. Epub 2016 Sep 29. PubMed PMID:
27688402; PubMed Central PMCID: PMC5066613.
2016
Winter PB, Brielmann RM, Timkovich NP, Navarro HT, Teixeira-Castro A, et al. A network approach to discerning the identities of C. elegans in a free moving population. Sci Rep. 2016 Oct 11;6:34859. doi: 10.1038/srep34859. PubMed PMID: 27725712; PubMed Central PMCID: PMC5057085.2016
Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M.A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11. PubMed PMID: 27071083; PubMed Central PMCID: PMC4855616.2016
Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L,
Silva-Fernandes A, et al.
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain. 2015 Nov;138(Pt 11):3221-37. doi: 10.1093/brain/awv262. Epub 2015 Sep 15. PubMed PMID: 26373603; PubMed Central PMCID: PMC4731417.2015
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, et al. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5. PubMed PMID: 26245380; PubMed Central PMCID: PMC4830470.2015
Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, et al. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29. PubMed PMID: 26228940; PubMed Central PMCID: PMC4570520.2015
Brandvold KR, Morimoto RI.The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol. 2015 Sep 11;427(18):2931-47. doi: 10.1016/j.jmb.2015.05.010. Epub 2015 May 21. Review. PubMed PMID: 26003923; PubMed Central PMCID: PMC4569545.2015
Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, et al. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032. Erratum in: Cell. 2017 Feb 23;168(5):944. PubMed PMID: 25957690; PubMed Central PMCID: PMC4643853.2015
Labbadia J, Morimoto RI. The biology of proteostasis in aging and disease. Annu Rev Biochem. 2015;84:435-64. doi: 10.1146/annurev-biochem-060614-033955. Epub 2015 Mar 12. Review. PubMed PMID: 25784053; PubMed Central PMCID: PMC4539002.2015
van Oosten-Hawle P, Morimoto RI. Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes Dev. 2014 Jul 15;28(14):1533-43. doi: 10.1101/gad.241125.114. Review. PubMed PMID: 25030693; PubMed Central PMCID: PMC4102760.2014
Labbadia J, Morimoto RI. Proteostasis and longevity: when does aging really begin? F1000Prime Rep. 2014 Feb 3;6:7. doi: 10.12703/P6-7. eCollection 2014. Review. PubMed PMID: 24592319; PubMed Central PMCID: PMC3914504.2014
Morimoto RI, Cuervo AM.Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):167-70. doi: 10.1093/gerona/gln071. Epub 2009 Feb 19. Review. PubMed PMID: 19228787; PubMed Central PMCID: PMC2655025.2009
Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science. 2008 Feb 15;319(5865):916-9. doi: 10.1126/science.1141448. Review. PubMed PMID: 18276881.2008
Sinnige T, Yu A, Morimoto RI.Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease2020
Sala AJ, Bott LC, Morimoto RI.Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience 2020
Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP.Amplifiers Co-Translationally Enhance CFTR Biosynthesis via PCBP1-mediated Regulation of CFTR mRNA 2020
Ciryam P, Antalek M, Cid F, Tartaglia GG, Dobson CM, Guettsches AK, Eggers B, Vorgerd M, Marcus K, Kley RA, Morimoto RI, Vendruscolo M, Weihl CC.A Metastable Subproteome Underlies Inclusion Formation in Muscle Proteinopathies 2019
Morimoto, RI.Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease 2020
Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, Morimoto RI.Tau Protein Aggregates Inhibit the Protein-Folding and Vesicular Trafficking Arms of the Cellular Proteostasis Network 2019
Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL.Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing 2019
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliveira AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S.Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease2020
Finkbeiner S.The Autophagy Lysosomal Pathway and Neurodegeneration 2020
Elia LP, Reisine T, Alijagic A, Finkbeiner S.Approaches to Develop Therapeutics to Treat Frontotemporal Dementia 2020
Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW.Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD2019
Reisine T, Finkbeiner S. Cell death assays for neurodegenerative disease drug discovery.2019
Linsley JW, Tripathi A, Epstein I, Schmunk G, Mount E, Campioni M, Oza V, Barch M, Javaherian A, Nowakowski TJ, Samsi S, Finkbeiner S.Automated Four-Dimensional Long Term Imaging Enables Single Cell Tracking Within Organotypic Brain Slices to Study Neurodevelopment and Degeneration 2019
Elia LP, Mason AR, Alijagic A, Finkbeiner S.Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway2019
Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein 2018
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliviera AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. Deubiquitinase Usp12 Functions Noncatalytically to Induce Autophagy and Confer Neuroprotection in Models of Huntington's Disease2018
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders2018
Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D, Phatnani H, Kwan J, Sareen D, Broach JR, Simmons Z, Arcila-Londono X, Lee EB, Van Deerlin VM, Shneider NA, Fraenkel E, Ostrow LW, Baas F, Zaitlen N, Berry JD, Malaspina A, Fratta P, Cox GA, Thompson LM, Finkbeiner S, Dardiotis E, Miller TM, Chandran S, Pal S, Hornstein E, MacGowan DJ, Heiman-Patterson T, Hammell MG, Patsopoulos NA, Dubnau J, Nath A, Phatnani H, Shneider NA, Manley JL. Unexpected Similarities Between C9ORF72 and Sporadic Forms of ALS/FTD Suggest a Common Disease Mechanism 2018
Epstein I, Finkbeiner S. The Arc of Cognition: Signaling Cascades Regulating Arc and Implications for Cognitive Function and Disease 2018
Christiansen EM, Yang SJ, Ando DM, Javaherian A, Skibinski G, Lipnick S, Mount E, O'Neil A, Shah K, Lee AK, Goyal P, Fedus W, Poplin R, Esteva A, Berndl M, Rubin LL, Nelson P, Finkbeiner S.In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images 2018
Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L, Moreno CAM, Kamalakaran S, Goldstein DB, Gitler AD, Harris T, Myers RM, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE.Genome-wide Analyses Identify KIF5A as a Novel ALS Gene 2018
ang SJ, Berndl M, Michael Ando D, Barch M, Narayanaswamy A, Christiansen E, Hoyer S, Roat C, Hung J, Rueden CT, Shankar A, Finkbeiner S, Nelson P. Assessing Microscope Image Focus Quality With Deep Learning2018
Cobb MM, Ravisankar A, Skibinski G, Finkbeiner S. iPS Cells in the Study of PD Molecular Pathogenesis2018