| Author/s | Publication Title | Year |
|---|---|---|
| The Proteostasis Consortium, Overall coordination, Elsasser, S, Elia, L P, Morimoto, R I, Powers, E T, Harvard Medical School group, Elsasser, S, Finley, D, University of California, San Francisco and Gladstone Institutes group I, Costa, B, Budron, M, Tokuno, Z, Wang, S, Iyer, R G, Barth, B, Mockler, E, Elia, L P, Finkbeiner, S, University of California, San Francisco group II, Gestwicki, J E, Northwestern University group, Richardson, R A K, Stoeger, T, Morimoto, R I, The Scripps Research Institute group, Tan, E P, Xiao, Q, Cole, C M, Massey, L A, Garza, D, Powers, E T, Kelly, J W, Stanford University group, Rainbolt, K, Chou, C C, Masto, V B, Frydman, J, New York University group, Nixon, R A | A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway | 2023 |
| Morimoto RI, Finkbeiner S, Finley D, Frydman J, Gestwicki J, Kelly J, Powers EA | Translation of Proteostasis Mechanisms for Age-Associated Protein Conformational Diseases. Molecular Cell (invited, 2023) | 2023 |
| Elsasser S, Stoeger T, Mockler E, Lima L, Cao K, Collier M, Rainbolt TK, Massey L, the Proteostasis Consortium, Garza D, Finkbeiner S, Finley D, Frydman J, Gestwicki J, Kelly J, Morimoto RI, Powers EA | Comprehensive Enumeration of the Components of the Human Proteostasis Network I. Components of Translation, Protein Folding and Organelle-Specific Systems. bioRxiv (2022) - for Molecular Cell Resources | 2022 |
| Sui X, Prado, MA, Paulo, JA, Gygi, SP, Finley, D, Morimoto, RI | Global Proteome Metastability Response in Isogenic Animals to Missense Mutations and Polyglutamine Expansions in Aging. bioRxiv (2022) | 2022 |
| Botham RC, Yoon L, Verhelle A, Xu J, Sanz-Martinez P, Massey LA, Cuoco CA, Cole CM, Tan EP, Labra S, Elia LP, Ta A, Ardejani MS, Lee K, Kline GM, Xiao Q, Lyang NJ, Hou WC, Yu A, Fox S, Wulkop-Gil C, Ibrahim LH, Jiang S, Nelson LT, Peng H, Lipton SA, Bollong MJ, Hansen M, Morimoto RI, Petrassi HM, Wiseman RL, Powers ET, Finkbeiner S, Garza D, Finley D, Prado MA, Dikic I, Johnson KA, Frydman J, Silva MC, Haggarty SJ, Stolz A, Encalada SE, Kelly JW. | mTOR Inhibitor-Independent Macroautophagy Activator Ameliorates Cellular Tauopathy and Prionopathy Neurodegeneration Phenotypes. bioRxiv (2022), submitted to Cell – Oct. 2022 | 2022 |
| Finkbeiner S, Finley D, Frydman J, Garza D, Gestwicki J, Kelly J, Morimoto RI, Powers EA. | Chemical Probes for the Proteostasis Network. Trends in Biochemical Sciences (invited, 2022). | 2022 |
| Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J. | A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities | 2022 |
| Vest RT, Chou CC, Zhang H, Haney MS, Li L, Laqtom NN, Chang B, Shuken S, Nguyen A, Yerra L, Yang AC, Green C, Tanga M, Abu-Remaileh M, Bassik MC, Frydman J, Luo J, Wyss-Coray T. | Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration | 2022 |
| Stein KC, Morales-Polanco F, van der Lienden J, Rainbolt TK, Frydman J | Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis | 2021 |
| Powers, E. T.; Gierasch, L. M. | The Proteome Folding Problem and Cellular Proteostasis | 2021 |
| Loguercio, S., D. M. Hutt, A. R. Campos, T. Stoeger, R. A. Grant, A. C. McQuattie-Pimentel, H. Abdala-Valencia, Z. Lu, N. Joshi, K. Ridge, N. S. Chandel, J. I. Sznajder, R. I. Morimoto, A. V. Misharin, G.R. S. Budinger, and W. E. Balch | Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease. (in review, 2021) | 2021 |
| Stoeger, T, R. A. Grant, A. C. McQuattie-Pimentel, K. Anekalla, S. S. Liu, H. Tejedor-Navarro, B. Singer, H. Abdala-Valencia, M. Schwake, M. P. Tetreault, H. Perlman, W. E. Balch, N. Chandel, K. Ridge, J. I. Sznajder, R. I. Morimoto, A. V. Misharin, G. R. S. Budinger, and L. A. Nunes Amaral | Aging is Associated with a Systemic Length-Associated Transcriptome Imbalance. (in revision, 2021) | 2021 |
| Capano, L. S., C. Sato, E. Ficulle, A. Yu, K. Horie, N. R. Barthelemy, S. G. Fox, C. M. Karch, R. J. Bateman, H. Houlden, R. I. Morimoto, D. M. Holtzman, K. E. Duff, and A. S. Yoo | Recapitulation of Endogenous 4R Tau Expression Analogous to the Adult Brain in Directly Reprogrammed Human Neurons. (in revision, 2021) | 2021 |
| Morimoto, R.I., and G.S. Budinger | Protein Folding Disorders. Harrison’s Principles of Internal Medicine (eds. J. Loscalzo, A. Fauci, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson) (in press, 2021) | 2021 |
| Bott, L.C., M. Forouhan, M. Lieto, A. J. Sala, R. Ellerington, J. O. Johnson, A. A. Speciale, C. Criscuolo, A. Filla, D. Chitayat, A. Nemeth, Italian Undiagnosed Rare Diseases Network, F. Angelucci, W. F. Lim, P. Striano, M. Muona, C. Courage, A.-E. Lehesjoki, S. F. Berkovic, B. J. Traynor, K. H. Fischbeck, R. I. Morimoto, M. J. A. Wood, and C. Rinaldi | Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy | 2021 |
| Sala, A.J. and R.I. Morimoto | Protecting the future: balancing proteostasis for reproduction | 2021 |
| Aman, Y., T. Schmauck-Medina1†, M. Hansen, R. I. Morimoto, A. K. Simon, I. Bjedov, K. Palikaras, A. Simonsen, T. Johansen, N. Tavernarakis, D. C. Rubinsztein, L. Partridge, G. Kroemer, J. Labbadia and E. F. Fang | Autophagy in healthy aging and disease | 2021 |
| Lior, C., F. Hodge, E. A. De-Souza, D. Bourboulia, S. K Calderwood, D. David, D. A. Drummond, A. Edkins, R. I. Morimoto, V. Prahlad, O. Rechavi, L. Sistonen, M. Wilson, R. L. Wiseman, M. Zanetti, R. Taylor, R. Scherz-Shouval, and P.van Oosten-Hawle | The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021 | 2021 |
| Watanabe, S., N. S. Markov, Z. Lu, R. P. Aillon, S. Soberanes, C. Runyan, Z. Ren, R. A. Grant, M. Maciel, H. Abdala-Valencia, Y. Politanska, K. Nam, L. Sichizya, H. G. Kihshen, N. Joshi, A. C. McQuattie-Pimentel, R. I. Morimoto, P. A. Reyfman, G. R. S. Budinger, and A. V. Misharin | Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis | 2021 |
| Sinnige, T., G. Meisl, T. C. T. Michaels, M. Vendruscolo, T. P.J. Knowles, and R. I. Morimoto | Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans | 2021 |
| McQuattie-Pimentel, A.C., Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, C. E. Runyan, H. Abdala-Valencia, A. Y. Meliton, D. R. Winter, R. I. Morimoto, G. M. Mutlu, A. Bharat, H. Perlman, K. M. Ridge, N. S. Chandel, J. I. Sznajder, W. E. Balch, B. D. Singer, A. V. Misharin, and G. R. S. Budinger. | The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging | 2021 |
| Linsley JW, Linsley DA, Lamstein J, Ryan G, Shah K, Castello NA, Oza V, Kalra J, Wang S, Tokuno Z, Javaherian A, Serre T, Finkbeiner S. | Superhuman cell death detection with biomarker-optimized neural networks | 2021 |
| Novak G, Finkbeiner S, Skibinski G, Skupin A. | Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson's disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007) | 2021 |
| Novak G, Finkbeiner S, Skibinski G, Skupin A. | Generation of two human induced pluripotent stem cell lines from fibroblasts of unrelated Parkinson's patients carrying the G2019S mutation in the LRRK2 gene (LCSBi005, LCSBi006) | 2021 |
| Reed X, Cobb MM, Skinbinski G, Roosen D, Kaganovich A, Ding J, Finkbeiner S, Cookson MR | Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched | 2021 |
| Markmiller S, Sathe S, Server KL, Nguyen TB, Fulzele A, Cody N, Javaherian A, Broski S, Finkbeiner S, Bennett EJ, Lécuyer E, Yeo GW. | Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress | 2021 |
| Linsley JW, Shah K, Castello N, Chan M, Haddad D, Doric Z, Wang S, Leks W, Mancini J, Oza V, Javaherian A, Nakamura K, Kokel D, Finkbeiner S. | Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration | 2021 |
| Barch M, Cobb MM, Tokuno Z, Leddy J, Prenton K, Manubens-Gil L, Bellini N, Lam S, Kaye J, Dierssen M, Finkbeiner S. | A deep learning approach to neurite prediction in high throughput fluorescence imaging | 2021 |
| Sinnige T, Yu A, Morimoto RI. | Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease | 2020 |
| Sala AJ, Bott LC, Morimoto RI. | Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience | 2020 |
| Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP. | Amplifiers Co-Translationally Enhance CFTR Biosynthesis via PCBP1-mediated Regulation of CFTR mRNA | 2020 |
| Morimoto, RI. | Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease | 2020 |
| Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliveira AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. | Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease | 2020 |
| Finkbeiner S. | The Autophagy Lysosomal Pathway and Neurodegeneration | 2020 |
| Elia LP, Reisine T, Alijagic A, Finkbeiner S. | Approaches to Develop Therapeutics to Treat Frontotemporal Dementia | 2020 |
| Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. | Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. | 2020 |
| Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. | Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. | 2020 |
| Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, Finley D, Monteiro MJ. | ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function. | 2020 |
| Li Y, Lan Q, Gao Y, Xu C, Xu Z, Wang Y, Chang L, Wu J, Deng Z, He F, Finley D, Xu P. | Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation | 2020 |
| Wu GH, Mitchell PG, Galaz-Montoya JG, Hecksel CW, Sontag EM, Gangadharan V, Marshman J, Mankus D, Bisher ME, Lytton-Jean AKR, Frydman J, Czymmek K, Chiu W. | Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells. | 2020 |
| Vonk WIM, Rainbolt TK, Dolan PT, Webb AE, Brunet A, Frydman J. | Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network. | 2020 |
| Dalton K, Lopez T, Pande V, Frydman J. | REP-X: An Evolution-guided Strategy for the Rational Design of Cysteine-less Protein Variants. | 2020 |
| Rainbolt TK, Frydman J. | Dynamics and clustering of IRE1α during ER stress. | 2020 |
| Finkbeiner S. | Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease. | 2020 |
| Elia, L.P., Mason, A.R., Amela, A., Finkbeiner, S. | Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway | 2019 |
| Ciryam P, Antalek M, Cid F, Tartaglia GG, Dobson CM, Guettsches AK, Eggers B, Vorgerd M, Marcus K, Kley RA, Morimoto RI, Vendruscolo M, Weihl CC. | A Metastable Subproteome Underlies Inclusion Formation in Muscle Proteinopathies | 2019 |
| Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, Morimoto RI. | Tau Protein Aggregates Inhibit the Protein-Folding and Vesicular Trafficking Arms of the Cellular Proteostasis Network | 2019 |
| Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. | Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing | 2019 |
| Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. | Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD | 2019 |
| Reisine T, Finkbeiner S. | Cell death assays for neurodegenerative disease drug discovery. | 2019 |
| Linsley JW, Tripathi A, Epstein I, Schmunk G, Mount E, Campioni M, Oza V, Barch M, Javaherian A, Nowakowski TJ, Samsi S, Finkbeiner S. | Automated Four-Dimensional Long Term Imaging Enables Single Cell Tracking Within Organotypic Brain Slices to Study Neurodevelopment and Degeneration | 2019 |
| Elia LP, Mason AR, Alijagic A, Finkbeiner S. | Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway | 2019 |
| Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, et al. | Soberanes et al., Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis, Cell Metabolism (2018), https://doi.org/10.1016/j.cmet.2018.09.019.(2018). | 2018 |
| Stoeger T, Gerlach M, Morimoto RI, Nunes Amaral LA. | Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol. 2018 Sep 18;16(9):e2006643. doi: 10.1371/journal.pbio.2006643. eCollection 2018 Sep. PubMed PMID: 30226837; PubMed Central PMCID: PMC6143198. | 2018 |
| Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. | The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein | 2018 |
| Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliviera AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. | Deubiquitinase Usp12 Functions Noncatalytically to Induce Autophagy and Confer Neuroprotection in Models of Huntington's Disease | 2018 |
| Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. | The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders | 2018 |
| Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D, Phatnani H, Kwan J, Sareen D, Broach JR, Simmons Z, Arcila-Londono X, Lee EB, Van Deerlin VM, Shneider NA, Fraenkel E, Ostrow LW, Baas F, Zaitlen N, Berry JD, Malaspina A, Fratta P, Cox GA, Thompson LM, Finkbeiner S, Dardiotis E, Miller TM, Chandran S, Pal S, Hornstein E, MacGowan DJ, Heiman-Patterson T, Hammell MG, Patsopoulos NA, Dubnau J, Nath A, Phatnani H, Shneider NA, Manley JL. | Unexpected Similarities Between C9ORF72 and Sporadic Forms of ALS/FTD Suggest a Common Disease Mechanism | 2018 |
| Epstein I, Finkbeiner S. | The Arc of Cognition: Signaling Cascades Regulating Arc and Implications for Cognitive Function and Disease | 2018 |
| Christiansen EM, Yang SJ, Ando DM, Javaherian A, Skibinski G, Lipnick S, Mount E, O'Neil A, Shah K, Lee AK, Goyal P, Fedus W, Poplin R, Esteva A, Berndl M, Rubin LL, Nelson P, Finkbeiner S. | In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images | 2018 |
| Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L, Moreno CAM, Kamalakaran S, Goldstein DB, Gitler AD, Harris T, Myers RM, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE. | Genome-wide Analyses Identify KIF5A as a Novel ALS Gene | 2018 |
| ang SJ, Berndl M, Michael Ando D, Barch M, Narayanaswamy A, Christiansen E, Hoyer S, Roat C, Hung J, Rueden CT, Shankar A, Finkbeiner S, Nelson P. | Assessing Microscope Image Focus Quality With Deep Learning | 2018 |
| Cobb MM, Ravisankar A, Skibinski G, Finkbeiner S. | iPS Cells in the Study of PD Molecular Pathogenesis | 2018 |
| Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. | Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038. PubMed PMID: 29117555; PubMed Central PMCID: PMC5726777. | 2017 |
| Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB. | In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10. PubMed PMID: 29024389; PubMed Central PMCID: PMC5676055. | 2017 |
| Li J, Labbadia J, Morimoto RI. | Rethinking HSF1 in Stress, Development, and Organismal Health. Trends Cell Biol. 2017 Dec;27(12):895-905. doi: 10.1016/j.tcb.2017.08.002. Epub 2017 Sep 7. Review. PubMed PMID: 28890254; PubMed Central PMCID: PMC5696061. | 2017 |
| Alves LGA, Winter PB, Ferreira LN, Brielmann RM, Morimoto RI, Amaral LAN. | Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress. Phys Rev E. 2017 Aug;96(2-1):022417. doi: 10.1103/PhysRevE.96.022417. Epub 2017 Aug 29. PubMed PMID: 28950588; PubMed Central PMCID: PMC6011659. | 2017 |
| Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, et al. | Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. PubMed PMID: 28694385; PubMed Central PMCID: PMC5551573. | 2017 |
| Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M. | Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26. PubMed PMID: 28652376; PubMed Central PMCID: PMC5514703. | 2017 |
| Sala AJ, Bott LC, Morimoto RI. | Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol. 2017 May 1;216(5):1231-1241. doi: 10.1083/jcb.201612111. Epub 2017 Apr 11. Review. PubMed PMID: 28400444; PubMed Central PMCID: PMC5412572. | 2017 |
| Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, et al. | Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10. PubMed PMID: 28396410; PubMed Central PMCID: PMC5441770. | 2017 |
| Li J, Chauve L, Phelps G, Brielmann RM, Morimoto RI. | E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Genes Dev. 2016 Sep 15;30(18):2062-2075. Epub 2016 Sep 29. PubMed PMID: 27688402; PubMed Central PMCID: PMC5066613. | 2016 |
| Winter PB, Brielmann RM, Timkovich NP, Navarro HT, Teixeira-Castro A, et al. | A network approach to discerning the identities of C. elegans in a free moving population. Sci Rep. 2016 Oct 11;6:34859. doi: 10.1038/srep34859. PubMed PMID: 27725712; PubMed Central PMCID: PMC5057085. | 2016 |
| Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M. | A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11. PubMed PMID: 27071083; PubMed Central PMCID: PMC4855616. | 2016 |
| Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, et al. | Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain. 2015 Nov;138(Pt 11):3221-37. doi: 10.1093/brain/awv262. Epub 2015 Sep 15. PubMed PMID: 26373603; PubMed Central PMCID: PMC4731417. | 2015 |
| Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, et al. | Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5. PubMed PMID: 26245380; PubMed Central PMCID: PMC4830470. | 2015 |
| Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, et al. | Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29. PubMed PMID: 26228940; PubMed Central PMCID: PMC4570520. | 2015 |
| Brandvold KR, Morimoto RI. | The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol. 2015 Sep 11;427(18):2931-47. doi: 10.1016/j.jmb.2015.05.010. Epub 2015 May 21. Review. PubMed PMID: 26003923; PubMed Central PMCID: PMC4569545. | 2015 |
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