The Proteostasis Network Annotation Subgroup of the Proteostasis Consortium was formed to create an accurate, complete, and up-to-date description of the components of the proteostasis network (PN). This network is made up of the systems that assist protein folding during biogenesis and in response to stress, as well as the machinery that traffics proteins through the cell and the machinery that catabolizes proteins that have become damaged, aggregated, or are simply no longer needed. The goal of our subgroup is to generate a complete enumeration of proteostasis network components and to curate the information that is available about these components, their interactions, and their response to stressors such as aging and neurodegenerative disease and to make this information publicly available via this website.
Pursuant to these goals, we will aggregate the information on the proteostasis network in publicly available databases containing genomic, transcriptomic, proteomic, interactomic, phenomic, and functional information about how the PN components interact with each other and their substrates, how the PN components are expressed, and how that expression changes under a variety of conditions with an emphasis on aging, Alzheimer’s disease, and Alzheimer’s-disease-related dementias. We will couple this knowledgebase to web-based visualization tools like Cytoscape and WikiPathways to enable researchers to interrogate the PN in a way that can be customized to suit their needs.”
Figure 1
If you would like more information about the work of this subgroup, please contact Evan Powers at epowers@scripps.edu
