Proteostasis in Aging and Neurodegenerative Disease
Aging is an enigma. It is an essential part of life and yet we struggle with the consequences of aging. Aging is the basis of innumerable age-associated diseases and strongly linked to the onset of neurodegenerative disease. We consider that many of these issues are rooted in age-dependent changes in protein biochemistry and the misfolding and aggregation that occurs in aging. This program project grant brings together an exceptional team to develop a fundamentally new approach to aging and decline in proteostasis as the basis for aggregation of Tau, SOD1 and polyglutamine proteins in neurodegenerative disease.
Team Projects
Proteostasis Network Annotation Subgroup
This subgroup was formed to create an accurate, complete, and up-to-date description of the components of the proteostasis network (PN). See also, https://www.proteostasisconsortium.com/pn-annotation/
Small Molecules Subgroup
The Proteostasis Regulator Subgroup of the Proteostasis Consortium was formed to direct and coordinate the discovery and characterization of small molecule modulators of the Proteostasis Network across members of the NIH PPG-Proteostasis of Aging and Neurodegenerative Diseases together with collaborators. See also, https://www.proteostasisconsortium.com/proteostasis-regulator-plates/
Research Projects
Project 1
Dissecting the aging-associated decline in cellular proteostasis
Project 2
The proteasome as a modulator of neurodegenerative disease
Project 3
The autophagy lysosomal pathway: Regulation by progranulin and its role in neurodegenerative disease
Project 4
Organismal proteostasis in aging and neurodegenerative diseases
Cores
Core A
Administration
Core B
Sensors and tools for proteostasis analysis
Core C
Phenotypic analysis and global proteostasis network assessment by TMT-MS3 proteomics
Core D
Proteostasis regulator small molecule pharmacology core
