New Tools for Proteostasis Research
About Us
Northwestern University was awarded a $12.6 million grant from the National Institute on Aging at the National Institutes of Health (NIH) with Harvard Medical School, Stanford University, the Gladstone Institutes at University of California, San Francisco and The Scripps Research Institute. Together, our research teams formed the Proteostasis Consortium, studying the role of protein quality control in human aging and neurodegenerative diseases such as Alzheimer’s disease.
The five-year grant was one of the NIH’s Program Project Grants, designed to bring together investigators to uniquely solve a big problem, with aging and the risk for age-associated diseases being an example of highest priority.
Northwestern’s Richard I. Morimoto now leads a team of scientists including Ana Maria Cuervo at Albert Einstein College of Medicine, Judith Frydman at Stanford University, Dan Finley at Harvard Medical School, Steve Finkbeiner at the Gladstone Institutes at University of California San Francisco, Jason Gestwicki at University of California San Francisco, and Jeff Kelly and Evan Powers at The Scripps Research Institute, continuing the work of the Proteostasis Consortium.
Team of Scientists
Ana Maria Cuervo, MD, PhD
Professor Developmental and Molecular Biology
Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases
Co-director of the Einstein Institute for Aging Research
Albert Einstein College of Medicine, New York
Steven Finkbeiner, MD, PhD
Director, Center for Systems and
Therapeutics & Taube/Koret Center
for Neurodegenerative Disease,
Gladstone Institutes
Professor, Departments of
Neurology and Physiology,
University of California, San Francisco
Daniel Finley, PhD
Professor of Cell Biology
Harvard Medical School
Judith Frydman, PhD
Donald Kennedy Chair in the School of Humanities and Sciences
Professor of Genetics and Biology
Stanford University
Jason Gestwicki, PhD
Associate Director of Academic Affairs
Professor, Department of Pharmaceutical Chemistry
University of California, San Francisco
Jeffery Kelly, PhD
Lita Annenberg Hazen Professor of Chemistry
The Scripps Research Institute
Richard I. Morimoto, PhD
Bill and Gayle Cook Professor of Biology
Director, Rice Institute for
Biomedical Research
Department of Molecular Biosciences, Northwestern University
Evan Powers, PhD
Institute Investigator
Department of Chemistry
California Campus
Scripps Research
Announcements
2024 Proteostasis Consortium Seminar Series Schedule
| Date | Speaker | Institution | Seminar Title |
|---|---|---|---|
| January 10, 2024 | Jaroslaw (Jarek) Marszalek | University of Gdańsk | Hsp70’s client binding cycle - insights from dissecting a highly specialized system |
| January 17, 2024 | Alessandro Ori | Genentech Inc. | The Aging Proteome |
| January 24, 2024 | Vadim Gladyshev | Harvard Medical School | Insights on aging, longevity and rejuvenation |
| February 21, 2024 | Elizabeth Rhoades | University of Pennsylvania | Modifying α-Synuclein to modulate function |
| February 28, 2024 | Ramanujan Hegde | MRC Laboratory of Molecular Biology | Biogenesis of the membrane proteome |
| April 17, 2024 | Yogesh Kulathu | University of Dundee | Regulation of ER homeostasis by UFM1, the enigmatic ubiquitin-like modifier |
| April 24-28, 2024 | Meeting registration | COLD SPRING HARBOR | Protein Homeostasis in Health and Disease |
| May 08, 2024 | Claudio Joazeiro | Center for Molecular Biology of Heidelberg University (ZMBH) | Ribosome-associated Quality Control (RQC): mechanisms, evolution, and role in neurodegeneration |
| July 7-11, 2024 | Meeting registration | FASEB | Protein Folding in the Cell |
| September 18, 2024 | Andrew Truman | University of North Carolina at Charlotte | Understanding the reciprocal interplay between the Hsp70 chaperone code and proteostasis |
| October 16, 2024 | Christina Woo | Harvard University | Investigation of protein damage modifications |
| November 06, 2024 | Ivan Dikic | Goethe University Frankfurt | TBA |
| November 13, 2024 | Rahul Samant | Babraham Institute | TBA |
PROTEOSTASIS CONSORTIUM WEEKLY SEMINAR SERIES (VIA ZOOM)
VIEW FULL SCHEDULE UNDER SEMINARS
RECORDINGS WILL BE POSTED 3 WEEKS AFTER LIVE SEMINAR DATE UNDER SEMINARS
Contact: Rebecca (rebecca.phend@northwestern.edu)
Principal Investigators
Contact Us
Proteostasis Consortium
Grant and Website Administrator
Rebecca Phend (rebecca.phend@northwestern.edu)
