May 6, 2020 – Richard Morimoto (Northwestern University)
Regulating Proteostasis in Health, Aging and Disease
May 13, 2020 – Steve Finkbeiner (UCSF Weill Institute for Neurosciences)
Single Cell Dynamics of Proteostasis in Neurodegeneration
May 20, 2020 – Judith Frydman (Stanford University)
Proteostasis of Viral Infection: Unfolding and Harnessing the Complex Virus-Chaperone Interplay
May 27, 2020 – Jeff Kelly (Scripps Research Institute)
Pharmacologic Progress in Modulating Proteostasis Network Function for Ameliorating Disease
June 10, 2020 – Manu Hegde (MRC Laboratory of Molecular Biology at the University of Cambridge)
Mechanisms of Membrane Protein Biogenesis
June 17, 2020 – Ulrich Hartl (Max Planck Institute)
Molecular Chaperones in Protein Folding and Quality Control
June 24, 2020 – Ivan Dikic (Goethe University Frankfurt)
SARS-CoV-2 Papain-like Protease Regulates Viral Spread and Innate Immunity
July 1, 2020 – Marc Diamond (University of Texas – Southwestern)
Tau Prions: The Origins of Seeds and Strains within a Monomer
July 8, 2020 – Wade Harper (Harvard Medical School)
Organelle and Proteome Remodeling During Nutrient Stress
July 15, 2020 – Anne Brunet ( Stanford University)
Mechanisms of Protein Homeostasis During Aging
July 22, 2020 – Elke Deuerling (University of Konstanz)
Molecular Strategies for Proteostasis Maintenance by Ribosome-Associated Chaperones
August 5, 2020 – Gabriela Chiosis (Memorial Sloan Kettering Cancer Center)
Molecular Strategies for Proteostasis Maintenance by Ribosome-Associated Chaperones
August 12, 2020 – Jason Gestwicki (University of California-San Francisco)
Targeting Protein Folding and Stability Using Small Molecules
August 19, 2020 – Anne Bertolotti (MRC Laboratory of Molecular Biology- Cambridge)
Boosting Protein Quality Control For Therapeutic Benefit
August 26, 2020 – James Shorter (University of Pennsylvania)
Combating Deleterious Phases
September 2, 2020 – Brad Hyman (Harvard University)
What Are the Critical Steps of Tau Propagation?
September 16, 2020 – David Ron (Cambridge Institute for Medical Research)
Manipulating the Integrated Stress Response – A Molecular Perspective
September 23, 2020 – Stephen Haggarty (Massachusetts General Hospital / Harvard Medical School)
Humanizing Drug Discovery for Proteinopathies & Targeted Protein Degradation
October 7, 2020 – Jonathan Weissman (HHMI of the Whitehead Institute at Massachusetts Institute of Technology)
Structure, Function and Mechanism of the EMC Reveals How it Coordinates Production of Membrane Proteins
October 14, 2020 – Li-Huei Tsai (Picower Institute – Massachusetts Institute of Technology)
Uncovering the Role of Alzheimer’s Disease Risk Genes Using Yeast, Stem Cells, and Human Brains
October 21, 2020 – Sandra Encalada (Scripps Research-California)
Neuronal Vulnerability in the Proteinopathies: Endo-lysosomal and Cytoskeletal Trafficking Pathways that Make or Break Intracellular Aggregates
October 28, 2020- Malene Hansen (Sanford Burnham Prebys)
Cellular Recycling: Role of Autophagy in Aging and Disease
November 4, 2020- Sheena Radford (Leeds)
Early Steps in Amyloid Assembly: The Achilles Heel of a Disease Mechanism
November 18, 2020- Len Neckers (NCI-NIH)
Targeting Hsp40/Hsp70 to Treat Hormone-Refractory Prostate Cancer
November 25, 2020- Kaz Nagata (JT Biohistory Research Hall/Kyoto Sangyo University)
Proteostasis to Organostasis: Cross-talk Between Proteostasis, Redox and Calcium Homeostasis in the ER
December 2, 2020- Tom Rapoport (Harvard)
Molecular Mechanism of ER-associated Protein Translocation
December 9, 2020- Hideki Taguchi (Tokyo Inst of Tech)
Nascent Chain-Induced Ribosome Dynamics Regulation
December 16, 2020- Daniel Hebert (UMASS Amherst)
N-glycans direct protein maturation and quality control in the early secretory pathway
January 6, 2021 – Peter Walter (HHMI-UCSF)
Targeting the cell’s stress pathways for therapeutic benefit
January 13, 2021 – Huda Zoghbi (Baylor College of Medicine)
Genetic and Biochemical Studies to Gain Insight into Neurodegenerative Disorders
January 20, 2021 –
Ritwick Sawarkar (MRC Cambridge)
Stress-Induced Transcriptional Attenuation (SITA)
and
Sharon Hung (Harvard University)
Reciprocal regulation between Ubp6 and the proteasome
January 27, 2021 – Bernd Bukau (ZMBH/DKFZ)
How newly synthesized proteins reach the native state in the cytosol
February 3, 2021- David Agard (UCSF)
To fold or not to fold: the mechanism of chaperone-mediated client activation revealed in atomic detail
February 10, 2021- John Hardy (University College of London)
Genetic analysis of late onset neurodegeneration implicates a failure of damage response
February 24, 2021 – Nicolas Lehrbach (Fred Hutchinson Cancer Research Center)Regulation of the proteasome by SKN-1A/Nrf1
March 3, 2021- Alison Goate (ICAHN School of Medicine at Mount Sinai)
What human genetics tells us about the causes of Alzheimer’s disease
March 10, 2021- Rohit Pappu (Washington University- St. Louis)
Phase transitions driven by unfolded proteins
March 17, 2021- Keith Blackwell (Harvard University)
Coordinating lipid and protein homeostasis to promote longevity
March 24, 2021- Roland Riek (ETH Zurich)
Structure activity relationship of protein aggregates
March 31, 2021- Susan Shao (Harvard Medical School)
Mechanisms of membrane protein sorting
April 7, 2021- Susan Ackerman (UC-San Diego Medical School)
Translation elongation defects and neurodegeneration
April 14, 2021- Alwin Köhler (Max Perutz Labs Vienna-Austria)
The role of phase separation in nuclear ubiquitin signaling
April 21, 2021- Rachel Klevit (University of Washington School of Medicine)
Quasi-order organizes small heat shock proteins for action
April 28, 2021- Lila Gierasch (University of Massachusetts- Amherst)
How Hsp70s recognize their substrates
May 5, 2021- Todd Golde (University of Florida)
New twists on old hypothesis – a “multiomic” informed view of AD and other neurodegenerative proteinopathies
May 12, 2021- Brenda Schulman (Max Planck Institute- Martinsreid)
Regulation by the ubiquitin system
May 19, 2021 – Don Cleveland (UCSD Health)
Chaperone-regulated phase separation and aggregation of TDP-4
May 26, 2021 – Thorsten Hoppe (University of Cologne)
Stressed Out: Proteostasis Regulation Mediated by RNA Silencing
June 2, 2021 – Andrew Dillin (Berkeley)
Coordinating the molecular mechanisms of aging for metazoa
June 9, 2021 – Cynthia Kenyon (Calico Labs)
Regulation of proteostasis in the immortal C. elegans germ lineage
June 16, 2021 – Daniel Gottschling (Calico Labs)
Untangling the web of lysosomal homeostasis
June 23, 2021 – David Holtzman (Washington University School of Medicine)
Effect of APOE in models with amyloid or tauopathy
June 30, 2021- Norbert Perrimon (Harvard Medical School)
Interorgan communication and the control of homeostasis in Drosophila
July 21, 2021-
Priyanka Narayan (NIH – NIDDK)
Understanding cellular mechanisms of risk in neurodegenerative disease
and
John Labbadia (University College London)
The benefits of a difficult start in life: identifying pathways that override the commitment to proteostasis collapse in C. elegans
July 28, 2021- Aaron Gitler (Stanford University)
Expanding mechanisms and therapeutic strategies for ALS
August 4, 2021-
Rebecca Taylor ((MRC Laboratory of Molecular Biology)
Mechanisms of organismal stress resistance in C. elegans
and
Jessica Young (University of Washington)
Sorting it out: Understanding AD genetic risk and endocytic network trafficking using human neuronal models
August 11, 2021- Darcie Moore (University of Wisconsin-Madison)
Aggresomes: a non-universal program for maintaining proteostasis
August 18, 2021- Noboru Mizushima (University of Tokyo)
Organelle degradation by autophagy-dependent and independent pathways
August 25, 2021- Byron Caughey (Rocky Mountain Laboratory)
Prion structures, strains, transmission barriers, and membrane interactions: can prions hide from proteostasis?
September 01, 2021-
Jeremy Linsley (UCSF – Gladstone Institute)
Deep Fish
and
Emily Sontag (Marquette University)
Sorting out the JUNQ: the Spatial Nature of Protein Quality Control
September 8, 2021- Matthias Mayer (University of Heidelberg)
Molecular mechanism of Hsp70 Chaperones: Interactions with cochaperones and substrates
September 15, 2021 – Daryl Bosco (University of Massachusetts Medical Center)
Mechanisms of protein dysfunction in ALS
September 22, 2021 – Toshi Inada (Tohoku University)
Translation quality control and ribosome ubiquitination
September 29, 2021 – Anne Simonsen (University of Oslo)
Regulation of selective autophagy by lipid-binding proteins
October 6, 2021 – Thomas Langer (Max Planck Institute- Cologne)
Reprogramming mitochondria by proteolysis
October 13, 2021 – D. Allan Drummond (The University of Chicago)
Stress-triggered mRNA condensation
October 20, 2021 – Helen Saibil (Birkbeck- University of London)
Protein aggregation and disaggregation in vivo and in vitro
October 27, 2021- Jeffrey Brodsky (University of Pittsburgh)
The many fates of misfolded proteins in the Endoplasmic Reticulum
November 3, 2021 – Christina Sigurdson (UC San Diego)
Manipulating prion protein clearance pathways to slow neurodegeneration
November 10, 2021 – Yihong Ye (NIH – NIDDK)
Protein misfolding in and out of the cell
November 17, 2021 – Onn Brandman (Stanford University)
Systems insights of PQC from yeast
December 1, 2021 – Randal Kaufman (Sanford Burnham Prebys Medical Discovery Institute)
Clotting factor VIII: From cloning to molecular therapy and beyond to liver disease
December 8, 2021 – Lea Sistonen (University of Turku)
Heat Shock Factors Regulate Unique and Common Targets, Both Genes and Enhancers, in Response to Heat Shock and Oxidative Stress
December 15, 2021 – James Chen (UT Southwestern)
Ubiquitin Signaling in Innate Immunity
January 12, 2022 – Adam Antebi (Max Planck Institute for Biology of Ageing)
Nucleolar regulation of longevity
January 26, 2022 – Andreas Martin (University of California, Berkeley)
Beyond just targeting: Ubiquitin modulates the conformational changes and substrate degradation of the 26S proteasome
February 2, 2022 – Gillian Bates (UCL Queen Square Institute of Neurology)
Targeting huntingtin as a therapeutic strategy for Huntington’s disease
February 9, 2022 – Lewis Kay (University of Toronto)
Solution NMR Reveals the Critical Role of Dynamics in Driving the Function of Molecular Machines
February 16, 2022 – Kim Orth (University of Texas Southwestern Medical Center)
From flies to mice: Fic-mediated AMPylation of BiP is an evolutionarily conserved mechanism used to tune a physiological response to stress in animals
February 23, 2022 – Adam Frost (UCSF)
Membrane-Associated Quality Control Mechanisms
March 2, 2022 – Hilal Lashuel (EPFL)
Rethinking drug discovery in neurodegenerative diseases: Challenges and opportunities
March 9, 2022 – Susan Ferro-Novick (UCSD)
ER-phagy limits the accumulation of misfolded protein condensates in the endoplasmic reticulum
March 16, 2022 – Ana Maria Cuervo (Albert Einstein College of Medicine)
Selective autophagy in aging and age-related diseases
March 23, 2022 – Evan Powers (Scripps Research)
The Proteostasis Network: Lists and Lessons
March 30, 2022 – Joel Buxbaum (Scripps Research)
Chaperones outside the cell: Professionals, Talented Amateurs, or Accidental Tourists
April 6, 2022 – Christine Vogel (New York University)
The ups and downs of protein expression regulation in response to misfolding stress
April 13, 2022 – Martin Kampmann (UCSF)
Uncovering mechanisms controlling protein aggregation by CRISPR-based functional genomics
April 20, 2022 – Carmela Sidrauski (Calico)
Mechanisms and Pathophysiology of the Integrated Stress Response
May 25, 2022 – Veena Prahlad (University of Iowa)
Linking cellular stress responses to systemic physiology: mechanisms and consequences
June 8, 2022 – Aimee Kao (UCSF)
Aging, Lysosomes and Neurodegenerative Disease
June 15, 2022 – Shu-oh Shan (Caltech)
Decision making at early stages of protein biogenesis
June 22, 2022 – Walid Houry (University of Toronto)
Development of novel anticancer compounds dysregulating protein homeostasis by targeting the human mitochondrial ClpP protease
June 29, 2022 – Randy Hampton (UCSD)
Leveraging Protein Quality Control for Biological Regulation: Mallostery and Metabolism
July 06, 2022 – Steven Johnson (Indiana University School of Medicine)
Exploring in vitro and intracellular inhibitor mechanisms to establish if GroEL/ES and HSP60/10 chaperonin systems are “druggable” targets
July 20, 2022 – Conrad (Chris) Weihl (Washington University)
Chaperonopathies associated with HSP40 mutations
July 27, 2022 – John Yates (Scripps Research)
Cystic Fibrosis Ion Transport Regulator
September 07, 2022 – Daniel Southworth (UCSF)
The structure and function of AAA+ protein disaggregase machines elucidated by cryo-EM
September 14, 2022 – Steve Finkbeiner (Gladstone Institutes)
Applications of Deep Learning for Proteostasis and Neurodegeneration Research
September 21, 2022 – Nancy Bonini (University of Pennsylvania)
Regulation of the stress response of the Drosophila brain by m⁶A
September 28, 2022 –
Lars Plate (Vanderbilt University )
Time-Resolved Interactomics to Elucidate Proteostasis Dynamic
and
Sue Ann Mok (University of Alberta)
Exploring the mutability of tau aggregate structures
October 05, 2022 – Ralph (Randy) Nixon (NYU)
Lysosome Dysfunction – a primary catalyst in Alzheimer’s Disease
October 19, 2022 –
Matthew Scaglion (Duke University)
SCA48 mutations reveal metamorphic properties of the E3 ligase CHIP
and
Amanda Woerman (University of Massachusetts Amherst)
Alpha-synuclein strain biology in multiple system atrophy
November 02, 2022 – Marina Rodnina (Max Plank Institute for Biophysical Chemistry, Göttingen)
Cotranslational protein folding
November 09, 2022 – Judith Steen (Harvard Medical School)
Tauopathy and Dementia: A story of Mice and (Wo)Men
December 07, 2022 – Nora Voegtle (Heidelberg University)
Cellular responses to mitochondrial proteotoxic stress
December 14, 2022 – Jeff Kelly (Scripps Research Institute)
Proteostasis Regulators to Ameliorate Loss-of-Function Proteinopathies
January 18, 2023 – Judith Frydman (Stanford University)
The TRiCky business of protein folding
January 25, 2023 – Jason Gestwicki (University of California, San Francisco)
Role of the anion environment in shaping aggregation of microtubule-associated protein tau
February 08, 2023 – Randal Halfmann (Stowers Institute)
Structure of a pathologic amyloid nucleus in vivo
February 15, 2023 – Malaiyalam Mariappan (Yale School of Medicine)
The role of ubiquitination in protein biogenesis
February 22, 2023 – Michael Rosen (UT Southwestern Medical Center)
Cell Organization by Liquid-Liquid Phase Separation
March 08, 2023 – Lila Gierasch and Daniel Hebert (University of Massachusetts Amherst)
Protein folding in the ER and roles of carbohydrate handles
March 15, 2023 – Stephanie Moon (University of Michigan)
Regulation of RNA in stress and disease
March 22, 2023 – Malene Hansen (Buck Institute)
Cellular recycling: Role of autophagy in aging and disease
March 29, 2023 – Frank Bennett (Ionis Pharmaceuticals)
Lessons from the Clinic: Antisense Drugs for Neurological Diseases
April 05, 2023 – Heather True (Washington University School of Medicine)
DNAJB6 in Muscular Dystrophy: Mechanistic Insights from Prion Strains
April 12, 2023 – Richard Youle (National Institutes of Health (NIH) )
From Mitophagy to Aggrephagy: How Autophagy can be Selectively Targeted
April 19, 2023 – Abigail Buchwalter (University of California, San Francisco)
Nature or nurture? Dissecting the influence of tissue context on protein lifetimes in health and disease
April 26, 2023 – Ursula Jakob (University of Michigan)
Polyphosphate – A Multifaceted Protein Scaffold
May 03, 2023 – Michael Petrascheck (Scripps Research Institute)
Targeting mRNA Translation to Modulate Aging and Proteostasis
May 10, 2023 – Ophir Shalem (University of Pennsylvania)
Direct measurement and perturbation of proteome dynamics by pooled gene tagging for unbiased exploration of cellular proteostasis
May 17, 2023 – Marc Mendillo (Northwestern University School of Medicine)
Delineating Mechanisms of Cancer Cell Stress Resilience
May 24, 2023 – Jack Taunton (University of California, San Francisco )
Trapped on the Ribosome
June 07, 2023 – Pedro Carvalho (University of Oxford)
Quality control of membrane proteins at the ER
June 14, 2023 – Tingwei Mu (Case Western University)
Proteostasis strategy to correct GABAA receptor protein folding diseases
June 21, 2023 – Elke Deuerling (University of Konstanz)
How newly synthesized proteins are sorted into the correct protein biogenesis pathway at the ribosome
June 28, 2023 – Joseph (Joey) Genereux (University of California, Riverside)
Quantifying Mistargeted Secretory Protein in Living Cells
September 06, 2023 – Luke Wiseman (Scripps Research Institute)
All Roads Lead to eIF2⍺: Compensatory Integrated Stress Response Kinase Activation in PERK deficiency
September 20, 2023 – Jill Johnson (University of Idaho)
Hsp90 and cochaperone regulation of client functions
September 27, 2023 – Sean Curran (University of Southern California)
WDR-23 gets some SKN in the game of the proteostasis network
October 11, 2023 – Sheena Radford (University of Leeds)
How does an IDP aggregate into amyloid? Insights from structural approaches
October 25, 2023 – Bernd Bukau (Center for Molecular Biology of Heidelberg University [ZMBH])
Nascent chain interaction networks studied by ribosome profiling
November 08, 2023 – Johannes Herrmann (University of Kaiserslautern)
Organized aggregation of mitochondrial proteins as a strategy to protect cellular proteostasis
November 29, 2023 – Patricija van Oosten-Hawle (University of North Carolina at Charlotte)
Deciphering Effectors of Transcellular Chaperone Signaling in Organismal Proteostasis
December 06, 2023 – Rubén Fernàndez Busnadiego (University of Göttingen)
Unravelling the structure of toxic protein aggregates in situ
December 13, 2023 – Kürşad Turgay (Max Planck Unit for the Science of Pathogens)
The many intricate strategies Bacillus subtilis cells use to respond and adjust to stress
January 10, 2024 – Jaroslaw (Jarek) Marszalek (University of Gdańsk)
Hsp70’s client binding cycle – insights from dissecting a highly specialized system
January 17, 2024 – Alessandro Ori (Genentech Inc.)
The Aging Proteome
January 24, 2024 – Vadim Gladyshev (Harvard Medical School)
Insights on aging, longevity and rejuvenation
February 21, 2024 – Elizabeth Rhoades (University of Pennsylvania)
Modifying α-Synuclein to modulate function
February 28, 2024 – Ramanujan Hegde (MRC Laboratory of Molecular Biology)
Biogenesis of the membrane proteome
April 17, 2024 – Yogesh Kulathu (University of Dundee)
Regulation of ER homeostasis by UFM1, the enigmatic ubiquitin-like modifier
