Protein Folding in the Cell- Southbridge, MA
In 1990, this conference was the first to bring together cell biologists, biophysical scientists, chemists, and physician-scientists from the global community to study this important discipline. Since then, organizers have continued to create programs every year that probe the basic scientific underpinning of the maintenance of cellular and extracellular proteostasis and to this day, remains the flagship conference in the field.
This year’s conference will focus on the latest developments regarding how native conformations of cellular and secreted proteins are achieved and maintained, and what occurs when aberrant protein conformations arise, such as those seen in Alzheimer’s Disease and dementias of aging. The meeting’s focus is on the basic science defining protein homeostasis, enabled by 2500 genes encoding the proteostasis network, comprising molecular chaperones and co-chaperones that make folding versus degradation decisions, the latter mediated by the proteasome and lysosome. A decline in proteostasis capacity is especially prominent during aging-associated disease settings, including Alzheimer’s Disease and related dementias, and understanding these mechanisms is highly relevant for developing new therapeutic strategies.
Special emphasis will be placed on both formal presentations and informal networking for fellow scientists to collaborate via discussions and group brainstorming sessions that will bring fresh and new ideas for the next generation of research. This meeting will also empower early-career scientists, especially those from historically excluded groups, to participate and present their research during the sessions.
Goals and Takeaways
· A general understanding of cellular proteostasis network function and regulation
· A deeper insight into how cellular proteostasis network dysfunction leads to dementia.
· New knowledge of how the proteostasis network and its regulation changes with aging.
· Strategies for addressing and ameliorating aging-associated neurodegenerative diseases.
Program Topics
· Folding Energy Landscapes with and without Chaperones
· Cellular Machineries of Protein Folding and Degradation
· Quality Control in Organelles
· Condensate Formation under Physiological and Pathological Conditions
· Protein Folding and Misfolding in Aging and Age-Associated Diseases
· Regulation of Protein Homeostasis in Aging
· Strategies for Ameliorating Aging-Associated Neurodegenerative Diseases
Workshops
Meet the Expert sessions will be held, covering topics such as career trajectory, grant writing, diversity, and inclusion.
Career Development Workshops will be held focusing on academic and industry career paths.
Keynote Speaker
David Agard, PhD, Professor, University of California, San Francisco, CA
Elke Deuerling, PhD, Professor, University of Konstanz, Germany
Ignite Career Forum (Pre-conference Workshop)
The Pre-conference Workshop, “Ignite Career Forum”, will be held on Sunday from 11 AM to 5 PM. Separate registration is required ($45 per person). Attendees may add the Ignite Career Forum during the registration process. Please check the Online Agenda for detailed information.
We invite graduate students, post-docs and research scientists to present their work in a friendly and collaborative environment in the form of a short talk (15 min). The best three talks will be awarded a spot in the main-meeting. We especially encourage scientists from historically excluded groups to apply. Cost of travel and meeting will be partially reimbursed for our invited speakers. Those interested in giving a talk must submit an abstract describing their research including a statement of diversity. The chair of the Ignite Career Forum will select talks from abstracts submitted by April 15th.
Location and Venue
Wellsworth Hotel (formerly the Southbridge Hotel & Conference Center)
14 Mechanic Street
Southbridge, MA 01550
USA
Important Dates
Abstract Submission Deadline for the Ignite Career Forum (Pre-meeting Workshop): April 15, 2024
Abstract Submission Deadline: May 12, 2024
Early Registration Closes: May 26, 2024
Last Day to Cancel Registration: June 17, 2024
Housing Deadline: June 23, 2024
Regular Registration Closes: July 2, 2024
Conference Organizers
Ursula Jakob, PhD
Patricia S. Yaeger Collegiate Professor
University of Michigan, Ann Arbor, MI
Jeffery Kelly, PhD
Lita Annenberg Hazen Professor of Chemistry
Scripps Research, La Jolla, CA
Molecular chaperones in cancer and protein quality control- Madrid, Spain
Molecular Chaperones in Cancer and Protein Quality Control
Dates: 10/06/2024 – 12/06/2024
Venue: CNIO Auditorium
Registration https://apps.cnio.es/eventos/form01.asp?ev=1&cev=333&idiomaForm=en
Application deadline May 27 2024
Abstract submission deadline May 16 2024
fee 200 Euro Students, CNIO staff and CNIO Alumni; 400 Euro Post-docs and Academia; 600 Euro Industry
Organizers Gabriela Chiosis, Memorial Sloan Kettering Institute, NY, US – Nabil Djouder, CNIO, Madrid, Spain – Judith Frydman, Stanford University, US – Oscar Llorca, CNIO, Madrid, Spain – Paul Workman,The Institute of Cancer Research, London, UK
Speakers:
Dr. Udai Banerji – The Institute of Cancer Research; The Royal Marsden NHS Foundation Trust
Dr. Jeffrey L. Brodsky – University of Pittsburgh, Kenneth P. Dietrich School of Arts and Sciences
Dr. Johannes Buchner – Technical University of Munich
Dr. Eugenia Clerico – University of Massachusetts Amherst
Dr. Benoit Coulombe – Montreal Clinical Research Institute (IRCM), University of Montreal
Dr. Chengkai Dai – Center for Cancer Research, National Cancer Institute
Dr. Elke Deuerling – Konstanz University
Dr. Manajit Hayer-Hartl – Max-Planck-Institute of Biochemistry
Dr. Walid Houry – Biochemistry, University of Toronto
Dr. Ursula Jakob – University of Michigan
Dr. Matthias Mayer – Center for Molecular Biology Heidelberg – ZMBH
Dr. Leonard Neckers – Center for Cancer Research, National Cancer Institute
Dr. Rahul Samant – Babraham Institute
Dr. Ritwick Sawarkar – University of Cambridge
Dr. Lea Sistonen – Turku Centre for Biotechnology
Dr. Peter Walter – Altos Lab, University of California
