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2020 Seminars

MAY 6 – RICK MORIMOTO (NORTHWESTERN)

The Biology of Proteostasis in Aging and Neurodegenerative Diseases

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MAY 13 – STEVE FINKBEINER (GLADSTONE – UCSF)

Single Cell Dynamics of Proteostasis in Neurodegeneration

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MAY 20 – JUDITH FRYDMAN (STANFORD)

Proteostasis of Viral Infection: Unfolding and Harnessing the Complex Virus-Chaperone Interplay

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MAY 27 – JEFF KELLY (SCRIPPS)

Pharmacologic Progress in Modulating Proteostasis Network Function for Ameliorating Disease

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JUNE 3 – DAN FINLEY (HARVARD)

Global Remodeling of the Proteome

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JUNE 10 – MANU HEGDE (MRC)

An Intramembrane Chaperone Complex Facilitates Membrane Protein Biogenesis at the ER

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JUNE 17 – ULRICH HARTL (MPI-MARTINSREID)

Molecular Chaperones in Protein Folding and Quality Control

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JUNE 24 – IVAN DIKIC (FRANKFURT)

Ubiquitin and Autophagy Networks in Proteostasis

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JULY 1 – MARC DIAMOND (UT SOUTHWESTERN)

Tau Prions: The Origins of Seeds and Strains within a Monomer

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JULY 8 – WADE HARPER (HARVARD)

Organelle and Proteome Remodelling During Nutrient Stress

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JULY 15 – ANNE BRUNET (STANFORD)

Mechanisms of Protein Homeostasis During Aging

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JULY 22 – ELKE DEUERLING (UNIVERSITÄT KONSTANZ)

Molecular Strategies for Proteostasis Maintenance by Ribosome-Associated Chaperones 

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AUG 5 –  GABRIELA CHIOSIS (MEMORIAL  SLOAN KETTERING)

Chaperome-Mediated Protein Connectivity Dysfunctions – From Mechanisms, To Detection and Treatment

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AUG 12 – JASON GESTWICKI (UCSF)

Targeting Protein Folding and Stability Using Small Molecules

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AUG 19 – ANNE BERTOLOTTI (MRC)

Boosting Protein Quality Control For Therapeutic Benefit

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AUG 26 – JIM SHORTER (PENN)

Combating Deleterious Phases

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SEPT  2 – BRAD HYMAN (MGH/HARVARD)

What Are the Critical Steps of Tau Propagation?

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SEPT 9 -Protein Society Webinar Series: Mechanisms of Molecular Chaperones: Insights from Hybrid Biophysical Approaches.

          September 9th registration: https://zoom.us/webinar/register/WN_L1ecbVt7RPuC58k80uOJkw
          September 10th registration: https://zoom.us/webinar/register/WN_dvHOgIIHTMuaXgy3aC0ufQ
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SEPT 16 – DAVID RON  (CAMBRIDGE)

Manipulating the Integrated Stress Response – A Molecular Perspective

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SEPT 23 – STEVE HAGGARTY (MGH/HARVARD)

Humanizing Drug Discovery for Proteinopathies & Targeted Protein Degradation

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SEPT 30 – URSULA JAKOB (MICHIGAN)

Effects of Early-life ROS on Aging and Age-related Diseases

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OCT 7- JONATHAN WEISSMAN (HHMI/WHITEHEAD/MIT)

Structure, Function and Mechanism of the EMC Reveals How it Coordinates Production of Membrane Proteins

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OCT 14 – LI-HUEI TSAI (PICOWER-MIT)

Uncovering the Role of Alzheimer’s Disease Risk Genes Using Yeast, Stem Cells, and Human Brains

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OCT 21 – SANDRA ENCALADA (SCRIPPS)

Neuronal Vulnerability in the Proteinopathies: Endo-lysosomal and Cytoskeletal Trafficking Pathways that Make or Break Intracellular Aggregates

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OCT 28 – MALENE HANSEN (SANFORD BURNHAM PREBYS)

Cellular Recycling: Role of Autophagy in Aging and Disease

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NOV 4 – SHEENA RADFORD (LEEDS)

Early Steps in Amyloid Assembly: The Achilles Heel of a Disease Mechanism

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NOV 11-14 Cold Spring Harbor Meeting on Protein Homeostasis in Health and Disease

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NOV 18 – LEN NECKERS (NCI-NIH)

Targeting Hsp40/Hsp70 to Treat Hormone-Refractory Prostate Cancer

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NOV 25 – KAZ NAGATA (JT BIOHISTORY RESEARCH HALL / KYOTO SANGYO UNIV.)

 Proteostasis to Organostasis: Cross-talk Between Proteostasis, Redox and Calcium Homeostasis in the ER

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DEC 2 – TOM RAPOPORT (HARVARD)

Molecular Mechanism of ER-associated Protein Translocation

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DEC 9-HIDEKI TAGUCHI (TOKYO INST OF TECH)

Nascent Chain-Induced Ribosome Dynamics Regulation

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DEC 16- DANIEL HEBERT (UMASS AMHERST)

 N-glycans direct protein maturation and quality control in the early secretory pathway

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