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Anticipated Postdoctoral or Research Associate Opportunities at Tufts University

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    rmb341
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    Anticipated Postdoctoral or Research Associate Opportunities at Tufts
    University, Graduate Sciences and Medical School Campus, Boston

    Our Center is currently officially open only with restricted access. These positions will
    activate when we are permitted to work in the building. We will start part time and then
    move to full time.

    Overview: The Lab for Nutrition and Vision Research seeks to discover mechanisms of aging,
    particularly applied to the eye, and to discover nutritional and other means to delay age-related
    vision impairments such as age-related macular degeneration and cataracts. To accomplish
    this, we elucidate relationships between environmental stress, physiologic stress responses,
    protein quality control and eye function. Projects are mature and much data is already
    available. Tufts Medical Center is a highly collaborative and productive environment in
    downtown Boston, within ~20 minutes from Harvard, MIT, Boston Univ.

    Position Description: The Lab for Nutrition and Vision Research at the Jean Mayer USDA
    Human Nutrition Research Center on Aging (JM-USDA HNRCA) at Tufts University, Boston, is
    seeking outstanding candidates with a recent PhD in Biochemistry or a related discipline to
    work on one of the following funded projects:
    1) Discovering novel stress-induced ubiquitin and autophagy enzyme interactions in response
    to glycative stress.
    2) Regulatory mechanisms of eye lens differentiation,
    3) Elucidate interactions between dietary glycemia, metabolomics, microbiome, AMD, cataract,
    aging in animal studies and/or human populations, including planning randomized intervention
    studies.

    Successful candidates will have some of the following qualifications: PhD in Biochemistry or a
    related discipline, good biochemical, histology skills, and experience analyzing large data sets.
    Scientists with bioinformatics experience are most desired. Candidates should have at least
    two English language first authored papers and 1 year of experience. The review of
    applications will start as soon as possible. A 2 year commitment is required Preference will be
    given to candidates who have permits to reside in the USA. If applicable, candidates must
    have or obtain a suitable visa.

    Recent papers from our group include:

    Rowan, S., et al., (2020) A low glycemic diet protects disease-prone Nrf2-deficient mice
    against age-related macular degeneration, Free Radical biology and Medicine in press
    PMID: 32068111 DOI: 10.1016/j.freeradbiomed.2020.02.010

    Aragonès, G. et al., Autophagic receptor p62 protects against glycation-derived toxicity and
    enhances viability, Aging Cell, in revision

    Whitcomb, E. A. et al. Stabilization of p27(Kip1)/CDKN1B by UBCH7/UBE2L3 catalyzed
    ubiquitinylation: a new paradigm in cell-cycle control. FASEB J. Off. Publ. Fed. Am.
    Soc. Exp. Biol. 33, 1235–1247 (2019). PMID: 30113882.

    Chiu, C.-J. et al. Studies of advanced glycation end products and oxidation biomarkers for type
    2 diabetes. Biofactors 44, 281–288 (2018). PMID: 29718545
    Rowan, S. et al. Involvement of a gut–retina axis in protection against dietary glycemia-
    induced age-related macular degeneration. Proc. Natl. Acad. Sci. 114, E4472 LP-E4481
    (2017). PMID: 28507131.

    Lyu, L. et al. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with
    lens fiber cell denucleation, leading to cataract. FASEB J. Off. Publ. Fed. Am. Soc.
    Exp. Biol. 30, 1087–1095 (2016). PMID: 26590164.

    Liu, K. et al. Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of
    calpain, dysregulated differentiation, and cataract. Proc. Natl. Acad. Sci. U. S. A. 112,
    1071–1076 (2015). PMID: 25583491.

    Shang, F. et al. Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin.
    J. Proteome Res. 13, 1177–1189 (2014). PMID: 24450463.

    Chaffee, B. R. et al. Nuclear removal during terminal lens fiber cell differentiation requires
    CDK1 activity: appropriating mitosis-related nuclear disassembly. Development 141,
    3388–3398 (2014). PMID: 25139855.

    Application Instructions: Please send a CV, names of three references (including PhD
    advisor and post doc mentor) and a list of grades received in Graduate Science courses to:

    Allen Taylor
    Director of the Nutrition and Vision Research Laboratory at the HNRCA
    Professor of Nutrition, Biochemistry, and Ophthalmology at Tufts University
    JM-USDA HNRCA, 711 Washington St, Boston, MA 02111
    allen.taylor@tufts.edu

    For questions about these positions, please contact Dr. Taylor at 617-566-3156, 617 784
    3199 3-5 PM Eastern Time.

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